Malaria Prevention Methods in the Gambia
While in the Gambia I met with various government officials, public health leaders, heads of various NGOs, and local health care officials. I also was given the chance to work in several clinics in the capital of The Gambia, Banjul. My original purpose was to learn about the health care system and disparities and struggles faced in a developing country. The more I attended meetings and worked on my research, it developed and grew. It became very obvious that malaria was one of the major health issues. I began gathering all the information on the struggle that people in The Gambia faced in relation to malaria.
~Debbie
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Malaria Prevention Methods in
The Gambia
Malaria epidemics have been devastating world populations since far before the discovery of malaria’s etiology by Alphonse Laveran in 1880 (World Health Organization [WHO], 2006). Today malaria is estimated to put 40% of the world population at risk and cause 350 to 500 million cases per year. Research has shown that there is an estimated 3 million deaths every year due to malaria. The mortality rate primarily burdens Africa, with up to 90% of the deaths occurring on the continent. The affliction is also globally felt amongst children under the age of five, who represent 90% of the deaths (Roll Back Malaria Partnership [RBM], 2005; The Global Fund, b). In total, malaria currently affects 109 countries and territories, which span continents around the world, except Antarctica and Australia (WHO, 2008). Throughout these areas, malaria disproportionately affects the poorest areas, with 58% of all cases occurring amongst the poorest 20% of the world (Roll Back Malaria Partnership, 2005; The Global Fund, a).
With Africa being the most affected by the infectious disease, it is known that 74% of the continents population lives in areas that are considered to be highly endemic for malaria and 19% or approximately 125 million people live in areas prone to epidemics (WHO: Regional Offices for Africa and Eastern Mediterranean, 2006). Malaria is estimated to cost as high as US$ 12 billion each year for African countries with an average annual reduction of 1.3% in economic growth (RBM, 2005; WHO: Regional Offices for Africa and Eastern Mediterranean, 2006). With 44% of the population residing in the African region living with under US$1 a day, there is a heavy financial burden due to the extremely elevated costs of malaria (WHO: Regional Office for Africa, 2006). Studies have shown that the economic burden to treat malaria can vary between US$1 and US$10 depending on the country a person resides in, and this is not including costs towards prevention methods (WHO: Regional Offices for Africa and Eastern Mediterranean, 2006).
The West African nation The Gambia feels the constant effect of malaria, with 100% of its population at risk. The Gambia is located along the cost of West Africa, geographically surrounded by Senegal, and it has an estimated population of 1,735,000 (United Nations [UN], 2006). Although exact statistics of malaria’s affect on The Gambia is not entirely known, it is estimated to cause 4% of all deaths in infants and 25% of all deaths in children under the age of 5. The country struggles to fight and manage malaria due to insufficient resources and funds (Department of State for Health and Social Welfare [DOSH], 2003). It was estimated in 1999 that 59.3% of the population lives on less than US$1 a day (WHO: Regional Office for Africa, 2006). The Human Development Index (HDI) ranks countries beyond their gross domestic product (GDP) and incorporates life expectancy, adult literacy and educational level. The Human Development Report ranks the country 155th out of 177 countries. The Gambia’s ranking places the country amongst the Low Human Development countries (United Nations Development Programme [UNDP], 2007). Moreover, the United Nations ranks The Gambia as one of the forty-nine Least Developed Countries in the world. To be included amongst this list, a country must have an average gross national income (GNI) of under US$745, low human capital status, and economic vulnerability (UN, 2006). Thus, the poverty stricken country is unable to allocate appropriate funding to fight malaria without assistance.
While countries across the world continue to struggle with the devastating effects of malaria, many are moving towards projects that will eradicate the disease from their country. The eradication of the disease would not only benefit the well-being of the people but also the economic status of the country (RBM, 2005; The Global Fund, b). Malaria interventions that work to control and eliminate the disease include prevention, accurate treatment, and surveillance and monitoring (RBM, 2005; WHO, 2008; WHO: Regional Offices for Africa and Eastern Mediterranean, 2006). The most common preventive methods used globally include insecticide treated bed nets, indoor residual spraying, and intermittent preventative treatment for pregnant women. Using a combination of these methods, The Gambia’s vision is that malaria will cease to be a burdensome health problem upon the population (DOSH, 2003). Upon visiting The Gambia, there is a vast amount of evidence showing the effect of malaria and the methods being taken to intervene. The purpose of this study was to gather information from studies, governmental policies, and personal interviews, and assess the use and access of the Gambian population to the preventive methods against malaria.
Literature Review
Malaria
Malaria is a parasitic disease that is transmitted by the female anopheline mosquito. The disease is caused by four species of the genus Plasmodium; they include P. falciparum, P. vivax, P. ovale, and P. malariae. The majority of the deaths from malaria are caused by P. falciparum. The parasite is spread when the infected female anopheline mosquito bites a human. While feeding, malaria sporozoites are released into the bloodstream, and they are rapidly carried to the liver, where they invade hepatocytes and cause an asymptomatic liver infection. The sporozoite asexually reproduces daughter merozoites, which eventually cause the hepatocyte to burst. The merozoites are released into the bloodstream, where they quickly invade erythrocytes. The merozoites rapidly replicate within the cells causing it to eventually burst (Khan & Lai; Rosenthal; White & Breman).
When the parasites reach a blood density level of approximately 50/ ?L of blood, the symptomatic stage begins. The merozoites continue to quickly replicate within the bloodstream and progress to the next stage called trophozoites. As the trophozoites continue to grow and enlarge, they take on species specific characteristics. About 48 hours after the primary erythrocyte infection, the parasite enters the schizont stage, where it progressively consumes all hemoglobin and occupies most erythrocytes. Through out the process, some of the merozoites differentiate into gametocytes. In this form, the parasites can be taken up by another anopheline mosquito and transmitted to a new human (Khan & Lai; Rosenthal; White & Breman).
The first symptoms of malaria to typically appear are headache, fatigue, abdominal discomfort, and muscle aches, followed by fever. Other common symptoms that may be seen are chills, malaise, chest pain, and diarrhea. Physical findings may also include signs of anemia, jaundice, and splenomegaly. Common laboratory findings include anemia, thrombocytopenia, increased erythrocyte sedimentation rate and plasma viscosity, and liver function abnormalities. Malaria is diagnosed based upon these symptoms and a positive blood smear. The most common diagnostic test is the Giemsa-stained blood smear, and the severity of malaria is determined loosely on the quantity of parasites present (Rosenthal; White & Breman).
Global Programs
To fight the malaria epidemic, programs have arisen from organizations to assist countries in the initiation of malaria policies, provide access to prevention and treatment supplies, and funding. One such program is the Roll Back Malaria Partnership which plays a substantial role in the fight against malaria. The program was launched in 1998 by the collaboration of the World Health Organization (WHO), the United Nations Children’s Fund (UNICEF), the United Nations Development Programme (UNDP), and the World Bank. The primary goal of the partnership is to halve the burden of malaria by 2010. By 2015, the goal is to have all malaria related Millennium Development Goals (MDGs) met. The goals include the eradication of extreme poverty, universal primary education, reduction of child mortality, maternal health improvement, combat diseases, and the development of global partnership for development (RBM, 2005).
In April 2000, Roll Back Malaria (RBM) held The African Summit in Abuja, Nigeria, where forty-four of the fifty countries affected by malaria in Africa attended. In attendance were either the Heads of State, Vice Presidents, Prime Ministers, or the Ministers of Health from each country. They agreed to commit effort toward RBM’s vision to halve all cases of malaria by 2010. Notably, they resolved to ensure that by 2005:
§ At least 60% of people suffering from malaria have access to affordable treatment within 24 hours of the onset of symptoms
§ At least 60% of at risk groups, primarily pregnant women and children under five years of age, are provided with a combination of personal and community protective measures
§ At least 60% of all pregnant women who are at risk, have access to intermittent preventative treatment (RBM, 2000)
In 2005, RBM released new goals which increased the values to at least 80% and that the burden from malaria would be halved compared with 2000 (RBM, 2005).
Another major contributor towards the fight against malaria is the Global Fund to Fight AIDS, Tuberculosis and Malaria. The Global Fund was initiated by the collaboration between the G8 countries, the African leaders, and the United Nations. Since it started in 2001, the Global Fund has brought in US$4.7 billion, and it has committed US$1.5 billion in funding to 154 programs and 93 countries worldwide (The Global Fund, b). The Gambia currently receives two sets of grants from the Global Fund. The initial grant was set up in 2004 to cover the coastal region of the country. In 2007, a second grant was added to target the remaining health divisions of the country. Both grants have heavy focuses on the implementation of prevention methods against malaria (The Global Fund, 2008a, 2008b).
Discussion
Indoor Residual Spraying
The Gambia’s primary goal in the prevention of malaria is vector control, which entails indoor residual spraying, insecticide treated bed nets, and intermittent preventative treatment for pregnant women (DOSH, 2003). Indoor residual spraying (IRS) is the process of applying long-acting insecticides on the indoor surfaces and roofs of all houses. The main effect results in the killing of the mosquitoes that enter the home and rest on the treated surfaces (WHO, 2006, 2008; WHO: Global Malaria Programme, 2006). To achieve maximum results from spraying, at least 80% of the local community needs sprayed (WHO: Regional Offices for Africa and Eastern Mediterranean, 2006; WHO: Global Malaria Programme, 2006). The effectiveness is also determined upon the acceptance of IRS by the local community and the willingness to continue to spray at least once or twice a year. Problems arise with IRS because the method can only be delivered by fully staffed and equipped services, which is not usually present in many countries. Continuous spraying tends to also lead to progressive refusal of the procedures within community homes (WHO, 2006, 2008).
Within the country, the WHO assists The Gambia in multiple forms of IRS. The Gambian WHO program provides instructions on the proper methods for spraying insecticides within the community houses and what type of insecticide should be used. Similar information is provided in the instructions on larvicide spraying (personal communication, June, 2008). In discussion with The National Malaria Control Program a representative acknowledged the programs recognition of the WHO recommendations, and it was stated that the program provides targeted adult spraying and larviciding by chemical and biological pesticides. Targeted areas for spaying are communities that are surrounded by rice fields and other key vectors (personal communication, June, 2008). The Chief Officer of Nursing confirmed that the Global Fund would be soon beginning to initiate IRS (personal communication, June, 2008). Detailed information on the areas and accurate amount of spraying that occurs has not been reported.
Insecticide Treated Nets
Personal protection interventions continue to be provided and promoted by multiple organizations. The use of insecticide treated bed nets (ITN) is a cost-effective method that is highly promoted. Mosquito bed nets are treated with insecticides to properly provide protection to the person sleeping underneath the net while the odor of the insecticide is used to attract mosquitoes. The widespread use of ITNs within the community assists in the reduction of the mosquito population (Wiseman, McElroy, Conteh and Stevens, 2006; WHO, 2006, 2008; WHO: Regional Offices for Africa and Eastern Mediterranean, 2006). The distribution of ITNs is promoted by many governments by waiving or reducing taxes and tariffs on bed nets, netting materials, and insecticides. RBM, WHO, and UNICEF have programs instated to deliver ITNs specifically to pregnant women and children under the age of five. The programs are in line with the Abuja targets to provide protective measures for the at risk groups (WHO: Regional Offices for Africa and Eastern Mediterranean, 2006).
The Gambia’s National Malaria Control Program (NMCP) has been working in coordination with the Global Fund, WHO, UNDP, UNICEF and other groups to work on the distribution of ITNs. Upon interviewing a representative from the NMCP, it was stated that the Gambian government has removed all taxes and tariffs on nets, insecticides and netting materials. They work with other organizations to direct mass national net dipping campaigns at no cost to the citizens. The campaigns are carried out by each of the six district health teams, which coordinate care for each region of the country (personal communication, June, 2008). The Chief Officer of Nursing stated that Global Fund has been imperative in the distribution of ITNs by giving them out for free, demonstrating how to use them, and instructing on how to soak them correctly in insecticide (personal communication, June, 2008). Upon inspection, ITNs were observed to be used in the health care system, including the Royal Victoria Teaching Hospital, The Jammeh Foundation Hospital, and the Fajikunda Medical Clinic.
Following the Abuja targets and the Global Fund recommendations, long-lasting ITNs (LLN) are given out free to all pregnant women and children under the age of five. According to data collected by the Global Fund, 155,636 LLNs have been distributed to children under the age of five in the coastal region of The Gambia since 2004, and 86,754 LLNs have been distributed to children under the age of five in the remaining health regions since 2007. Similarly, 46,787 LLNs have been distributed to pregnant women in the coastal region since 2004 and 7,976 in the remaining regions since 2007. The distribution of LLNs to pregnant women falls below the Global Funds target goals in all regions (The Global Fund, 2008a, 2008b). The Center for Innovation Against Malaria in Gambia found that the night before one of their studies only 48% of the women slept under an ITN (Center for Innovation Against Malaria [CIAM], 2007). The NMCP relates the issue to pregnant women having a lack of awareness of the benefits of ITNs, belief that the insecticide is harmful to their health, lack of desire to use ITNs, perception that bed nets are not fashionable, and view that netting materials are too expensive (DOSH, 2006a).
The national Malaria Control Policy states that the allocation of preventative methods, such as ITNs, is hampered in The Gambia due to the high levels of poverty. The non-marginalized population, which has to pay for ITNs, is less prone to own bed nets. It has been reported that 26% of households do not own a bed net and 65% of these households state they could not afford one (Wiseman et al., 2006). The Center for Innovation Against Malaria (CIAM) reports that the cost for one untreated bed net is estimated at 200 dalasi (at time of the study D1 ? US$34) and one LLN is estimated at D300. To treat bed nets yearly with deltamethrin (KO Tabs), an insecticide, costs D42; however, this cost is typically covered by the government or outside organizations during mass net dipping campaigns (CIAM, 2007b). While costs continue to deter people from purchasing ITNs, there has been minimal movement on eliminating this factor.
Intermittent Preventative Treatment
During pregnancy, malaria has an increased risk of adverse consequences. Normal presentation of the disease may occur, but the parasite may sequester in the placenta, causing complications to the fetus. Common complications include abortion, stillbirth, congenital infections, and intra-uterine growth retardation (DOSH, 2006b). To prevent malarial infection in pregnant women intermittent preventative treatment during pregnancy (IPTp) has been implemented. The standard regimen is a therapeutic dose of sulfadoxine-pyrimethamine (SP), commonly known as Fansidar, twice during pregnancy. The first dosage is administered after 16 weeks of gestation and before 28 weeks gestation, and the second dosage is administered from 28 weeks gestation to 34 weeks gestation. Proper administration to the women is ensured during scheduled ante-natal clinic appointments (DOSH, 2006b; RBM, 2005; The Global Fund, b; WHO: Regional Offices for Africa and Eastern Mediterranean, 2006).
In line with the national Malaria Control Policy goal to provide effective IPTp, The Gambia is working towards ensuring all pregnant women receive adequate care, which is influenced by the potential access and antenatal services available (CIAM, 2007a). According to the Global Fund report, 31 clinics in the coastal region of Gambia have implemented IPTp since 2004, and 37 clinics in the remaining regions have implemented the program since 2007, which accounts for 84% of the health clinics in these regions. In the coastal region, 51,700 pregnant women have been on IPTp since 2004, which is far above the goal of 29,600. In the remaining regions, 7,266 pregnant women have been on IPTp since 2007; however, the goal was for 20,025 pregnant women to be receiving the intervention. A common hurdle that must be overcome is pregnant women’s reluctance to take Fansidar. Many women have inadequate knowledge about the benefits of Fansidar and believe that it is dangerous to take during pregnancy. Desensitization is necessary to teach the community, specifically women, the benefits of taking the medication (DOSH, 2006a).
Recommendations
As technology continues to increase worldwide, new methods need to be implemented in the monitoring and surveillance of malaria within The Gambia. Low levels of data collection need to disappear and be replaced with detailed reports about the actualization of the effect of malaria on the Gambian population. Research also needs to be available to better identify what methods of intervention and prevention are most beneficial towards eradicating malaria. By identifying these methods, money can be properly budgeted and allocated to the accurate programs. Further research needs to be completed on the affects of IRS on the communities and environment to ensure that no damage is occurring. An increase in the monitoring of the distribution of ITNs is necessary to make certain that all members of vulnerable populations are being properly protected against malaria. Due to high levels of poverty, changes need to also occur in the access of ITNs by the general population that does not qualify as a vulnerable person. An increase in IPTp needs to occur by an increase in education about Fansidar, and the importance of ante-natal clinic visits needs to continue to be promoted.
Conclusion
As The Gambia continues to develop and progress economically, the people will begin to confront new and further dilemmas. However, the devastation of malaria will continue to be felt until proper control can be gained over the infectious disease. Through the assistance of organizations like Roll Back Malaria, the United Nations, and the Global Fund, the government of The Gambia will hopefully one day be able to state that malaria no longer exists amongst their population. The eradication of malaria will continue to be, not only Gambia’s vision, but countries across the world that continuously struggle with the disease. Unremitting and constant research needs to occur until a solution to the malaria epidemic can be found. Promotion of the ideas that will eliminate malaria needs to exponentially grow in hope that one day malaria will no longer be existent around the world.
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